Fibrinogen binding to intercellular adhesion molecule 1: implications for Plasmodium falciparum adhesion.
نویسندگان
چکیده
Intercellular adhesion molecule 1 (ICAM-1) is an endothelial cell adhesion molecule implicated in cerebral malaria. We investigated whether fibrinogen affects Plasmodium falciparum binding to ICAM-1, as the ICAM-1 binding sites of P. falciparum and fibrinogen overlap. We show that fibrinogen dramatically reduces P. falciparum adhesion to ICAM-1 under flow conditions.
منابع مشابه
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عنوان ژورنال:
- Infection and immunity
دوره 70 7 شماره
صفحات -
تاریخ انتشار 2002